地味ですが、なかなかどうして

[半袖ﾊﾟｼﾞｬﾏさん]

Size controllable polyion complex vesicles (PICsomes), composed of biocompatible poly(ethylene glycol) (PEG) and poly(amino acid)s, have an extremely prolonged lifetime in the bloodstream that enables them to accumulate effectively in tumors via the enhanced permeability and retention (EPR) effect. The purpose of this study was to use PICsomes to synthesize a highly sensitive MRI contrast agent for more precise tumor detection. We synthesized SPIO-Cy5-PICsomes (superparamagnetic iron oxide nanoparticle-loaded Cy5-cross-linked Nano-PICsomes) and characterized them using dynamic light scattering and transmission electron microscopy in vitro and evaluated their ability to detect subcutaneously grafted tumors in vivo with MRI. The transverse relaxivity (r2) of the SPIO-Cy5-PICsomes (r2 = 663 ± 28 mM− 1 s− 1) was 2.54 times higher than that of bare clinically-used SPIO.
SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)

Daisuke Kokuryoa, 1, Yasutaka Anrakub, 1, Akihiro Kishimurab, , , Sayaka Tanakac, Mitsunobu R. Kanoc, Jeff Kershawa, Nobuhiro Nishiyamad, Tsuneo Sagaa, Ichio Aokia, , , Kazunori Kataokab, e, ,